What it is
A gut microbial metabolite of ellagitannins (found in pomegranate, walnuts, and certain berries). Available as a dietary supplement (Mitopure) holding FDA GRAS status as a food ingredient.
How it works
Induces mitophagy (selective autophagy of damaged mitochondria) in preclinical models, leading to improved mitochondrial quality and skeletal muscle function in animal and human studies.
Where it's used
Used as a dietary supplement marketed for mitochondrial and muscle health. Studied in clinical trials for skeletal muscle endpoints in older adults.
FDA-approved use
Regulated as a dietary supplement; holds GRAS status as a food ingredient.
Tracking it
Urolithin A is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time.
Source
Public reference
Last reviewed 2026-06-11