What it is
An isoquinoline alkaloid found in plants such as Berberis (barberry) and goldenseal. Available as oral capsule and tablet supplements.
How it works
Activates AMP-activated protein kinase (AMPK) and inhibits mitochondrial complex I in preclinical models, producing effects on glucose uptake, lipogenesis, and gut microbiome composition.
Where it's used
Used as a dietary supplement marketed for glucose and lipid support. Studied in clinical trials with modest effects on hemoglobin A1c, LDL cholesterol, and blood pressure.
FDA-approved use
Regulated as a dietary supplement.
Tracking it
Berberine is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time.
Source
Public reference
Not medical advice. This page is an educational summary compiled from public
sources for people who log what they take. It is not a recommendation to use
Berberine, a dosing guide, or a substitute for a clinician.
How we source →
Last reviewed 2026-06-11