What it is
An investigational synthetic tetrapeptide that concentrates in the inner mitochondrial membrane. Supplied as a lyophilized powder or sterile solution in clinical trials.
How it works
Selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae architecture and improving electron transport chain efficiency and ATP production in preclinical models.
Where it's used
Under investigation for primary mitochondrial diseases including Barth syndrome and for dry age-related macular degeneration.
Regulatory status
Not FDA-approved; investigational compound in clinical trials.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with the supplied diluent prior to subcutaneous injection in trials.
Tracking it
SS-31 is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 2 hours, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11