What it is
A small-molecule AMP analog and AMP-activated protein kinase activator, not a true peptide despite community grouping. Supplied as a lyophilized powder.
How it works
Phosphorylated intracellularly to ZMP, which mimics AMP and allosterically activates AMP-activated protein kinase (AMPK), influencing fatty acid oxidation, glucose uptake, and mitochondrial biogenesis in preclinical models.
Where it's used
Studied in preclinical and early clinical research for metabolic and cardioprotective effects. Listed on the WADA prohibited list.
Regulatory status
Not FDA-approved; research compound.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with sterile water or bacteriostatic water prior to use.
Tracking it
AICAR is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem.
Source
Public reference
Last reviewed 2026-06-11