What it is
A naturally occurring polyamine found in wheat germ and other foods. Available as a dietary supplement in capsule or wheat-germ-extract form.
How it works
Induces autophagy in preclinical models through inhibition of acetyltransferase EP300 and other mechanisms, with downstream effects on cellular proteostasis and lipid metabolism.
Where it's used
Used as a dietary supplement marketed for longevity and autophagy support. Studied in observational and small clinical trials for cardiovascular and cognitive endpoints.
FDA-approved use
Regulated as a dietary supplement.
Tracking it
Spermidine is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time.
Source
Public reference
Not medical advice. This page is an educational summary compiled from public
sources for people who log what they take. It is not a recommendation to use
Spermidine, a dosing guide, or a substitute for a clinician.
How we source →
Last reviewed 2026-06-11