What it is
A synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone. Supplied as a lyophilized powder.
How it works
Binds GHRH receptors on pituitary somatotrophs, stimulating endogenous growth hormone release in a physiologic pulsatile pattern.
Where it's used
Historically used in pediatric growth hormone deficiency diagnostic testing and treatment. Currently used off-label by some compounding pharmacies.
FDA-approved use
Previously FDA-approved (Geref) for pediatric growth hormone deficiency; marketed product was discontinued. Currently available via compounding pharmacies.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with bacteriostatic or sterile water prior to use.
Tracking it
Sermorelin is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 12 minutes, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11