What it is
A direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+). Regulatory status has shifted; in 2022 the FDA stated NMN is no longer permitted as a dietary supplement after being a drug investigational article, though enforcement is variable.
How it works
Converted intracellularly to NAD+, a redox cofactor required by sirtuins, PARPs, and CD38 and by mitochondrial electron transport. NMN supplementation raises circulating and intracellular NAD+ in clinical studies.
Where it's used
Sold as a dietary supplement and studied in clinical trials for effects on NAD+ levels and metabolic endpoints in aging adults.
Regulatory status
Not FDA-approved; regulatory status as a dietary supplement is contested following FDA review.
Tracking it
NMN is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time.
Source
Public reference
Last reviewed 2026-06-11