What it is
A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, considered a mitochondrially-derived peptide. Supplied as a lyophilized powder.
How it works
Translocates to the nucleus under metabolic stress and is hypothesized to regulate AMPK signaling and folate-methionine pathways, influencing glucose and lipid metabolism in preclinical models.
Where it's used
Studied in preclinical research for roles in metabolic regulation and mitochondrial function.
Regulatory status
Not FDA-approved; research compound.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with bacteriostatic water prior to use.
Tracking it
MOTS-c is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem.
Source
Public reference
Last reviewed 2026-06-11