What it is
An orally bioavailable non-peptide growth hormone secretagogue, studied historically as an investigational drug.
How it works
Selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a), mimicking ghrelin to stimulate GH and IGF-1 release and increase appetite.
Where it's used
Investigated in clinical trials for sarcopenia, hip-fracture recovery, and frailty; did not achieve regulatory approval. Listed on the WADA prohibited list.
Regulatory status
Not FDA-approved; investigational compound. Sale as a dietary supplement is prohibited by the FDA.
Tracking it
MK-677 is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time. with a half-life of about 6 hours, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11