What it is
A synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH).
How it works
Non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R). MC1R activation stimulates melanin synthesis; MC4R activation can influence sexual response and appetite.
Where it's used
Studied in early research as a melanocortin receptor agonist; later development was discontinued in favor of derivatives such as bremelanotide and afamelanotide.
Regulatory status
Not FDA-approved; research compound.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with bacteriostatic water prior to use.
Tracking it
Melanotan II is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 1 hours, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11