What it is
A neuropeptide encoded by the KISS1 gene. The truncated kisspeptin-10 fragment is the form most commonly used in clinical research.
How it works
Activates the KISS1R (GPR54) receptor on hypothalamic GnRH neurons, triggering pulsatile GnRH release and downstream LH and FSH secretion.
Where it's used
Studied in clinical research as an upstream stimulator of the hypothalamic-pituitary-gonadal axis and as an investigational diagnostic agent in hypogonadotropic hypogonadism.
Regulatory status
Not FDA-approved; investigational compound.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with bacteriostatic water prior to use.
Tracking it
Kisspeptin is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 24 minutes, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11