What it is
The pure trans-isomer of clomiphene, a selective estrogen receptor modulator (SERM).
How it works
Antagonizes estrogen receptors at the hypothalamus and pituitary, disinhibiting GnRH release and thereby increasing LH, FSH, and endogenous testosterone production.
Where it's used
Investigated as a treatment for secondary hypogonadism in men who wish to preserve fertility. Frequently prescribed via compounding pharmacies.
Regulatory status
Not FDA-approved as a standalone drug; available through compounding pharmacies. Prior NDA was withdrawn.
Tracking it
Enclomiphene is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time. with a half-life of about 10 days (240 h), a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11