What it is
A selective estrogen receptor modulator (SERM) consisting of a mixture of two isomers (zuclomiphene and enclomiphene).
How it works
Blocks estrogen receptor feedback at the hypothalamus and pituitary, increasing pulsatile GnRH and downstream gonadotropin release.
Where it's used
Used for ovulation induction in anovulatory women. Off-label, used in men for secondary hypogonadism, particularly when fertility preservation is desired.
FDA-approved use
Treatment of ovulatory dysfunction in women desiring pregnancy.
Tracking it
Clomiphene is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time. with a half-life of about 5 days (120 h), a dose log also lets a tracker model the relative amount still in your system between doses.
Source
OpenFDA
Last reviewed 2026-06-11