What it is
A truncated analog of IGF-1 lacking the first three N-terminal amino acids. Supplied as a lyophilized powder.
How it works
Agonist of the IGF-1 receptor with reduced affinity for IGF binding proteins, leading to a short, intense burst of receptor activation when administered.
Where it's used
Used historically as a research reagent. Studied in preclinical research for IGF-1 receptor signaling with reduced binding-protein interaction.
Regulatory status
Not FDA-approved; research compound.
Reconstitution
Supplied as a lyophilized powder requiring reconstitution with bacteriostatic water or an acidic diluent prior to use.
Tracking it
IGF-1 DES is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 18 minutes, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11