What it is
A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). Supplied as a lyophilized powder or sterile solution.
How it works
Binds GnRH receptors on pituitary gonadotrophs, stimulating release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH in turn stimulates testicular Leydig cell testosterone production.
Where it's used
Historically used in diagnostic testing of pituitary function and in pulsatile therapy for hypothalamic hypogonadism. Compounded gonadorelin has become a common HCG alternative in US testosterone-therapy clinics.
FDA-approved use
Previously FDA-approved (Factrel) for diagnostic evaluation of pituitary gonadotropic function; original brand discontinued. Currently available primarily through compounding pharmacies in the US.
Reconstitution
Compounded lyophilized formulations are reconstituted with bacteriostatic water prior to subcutaneous injection.
Tracking it
Gonadorelin is injectable, so two things matter in a log: when you dosed and where. Rotating sites and writing both down prevents the classic “did I already pin the left side?” problem. with a half-life of about 4 minutes, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
Public reference
Last reviewed 2026-06-11