What it is
A naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) complexed with copper(II). Found in plasma and used in cosmetic formulations.
How it works
GHK has high affinity for copper and serves as a carrier; the complex is proposed to modulate gene expression related to skin remodeling, collagen synthesis, and antioxidant defense in preclinical studies.
Where it's used
Used in topical cosmetic products marketed for skin appearance. Studied in research for wound healing properties.
Regulatory status
Not FDA-approved as a drug; used as a cosmetic ingredient.
Reconstitution
Lyophilized injectable forms require reconstitution with bacteriostatic water; topical cosmetic formulations are pre-mixed.
Tracking it
Logging every administration of GHK-Cu builds the record that makes patterns visible.
Source
Public reference
Last reviewed 2026-06-11