Sermorelin vs Tesamorelin
Two peptides on the same pathway, separated mostly by how modern and how regulated each is. A useful factual comparison for anyone logging GH-axis compounds.
Side by side
| Sermorelin | Tesamorelin | |
|---|---|---|
| Class | Peptides | Peptides |
| Form | Injection | Injection |
| Half-life | ≈ 12 minutes | ≈ 30 minutes |
| Storage | — | — |
| Dose units | mcg, mg | mg |
| FDA status | Approved | Approved |
Facts from the Stack compound library. See the full pages: Sermorelin · Tesamorelin.
How they differ
Molecule
Sermorelin is a fragment of GHRH (the first 29 amino acids). Tesamorelin is a stabilized GHRH analog engineered for a longer functional life.
Approval
Tesamorelin has a specific FDA-approved indication; sermorelin's regulatory history is different. Each page states its status — read them rather than assuming.
Cadence
Both are injectable peptides reconstituted from powder, so the calculator, refrigeration and opened-vial dates apply to each.
Tracking
GH-axis peptides reward careful timing logs; record the dose, time and site each administration.
Tracking either one
Whichever you log, the workflow is the same in Stack: add it once, set the schedule, and let the app handle reminders, supply projection and an "in your system" curve from the half-life. Run both? Group them into one protocol you can pause together.
Track your stack in Stack
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Get the appLast reviewed 2026-06-11