What it is
A naturally occurring carboxylic acid form of vitamin A available as a topical cream, gel, or microsphere preparation, and as an oral capsule for oncologic use.
How it works
Binds nuclear retinoic acid receptors (RAR alpha, beta, gamma) to modulate gene transcription, influencing keratinocyte differentiation, comedone formation, collagen synthesis, and melanogenesis.
Where it's used
Topical formulations are used in acne vulgaris and photoaging. Oral tretinoin (Vesanoid) is used in acute promyelocytic leukemia.
FDA-approved use
Topical: acne vulgaris and palliation of fine wrinkles, mottled hyperpigmentation, and roughness of facial skin. Oral (Vesanoid): induction of remission in acute promyelocytic leukemia.
Tracking it
Logging every administration of Tretinoin builds the record that makes patterns visible. with a half-life of about 48 minutes, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
OpenFDA
Last reviewed 2026-06-11