What it is
A long-acting phosphodiesterase type 5 (PDE5) inhibitor available as oral tablets.
How it works
Selectively inhibits PDE5, increasing cyclic GMP in smooth muscle and producing vasodilation in the corpus cavernosum, prostate, bladder neck, and pulmonary vasculature.
Where it's used
Used in erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Low-dose daily formulations are FDA-approved for ED and BPH.
FDA-approved use
Erectile dysfunction (Cialis, including as-needed and once-daily dosing), benign prostatic hyperplasia (Cialis once-daily), and pulmonary arterial hypertension (Adcirca, Alyq).
Tracking it
Tadalafil is oral, which makes consistency the whole game — a simple daily check-off with a reminder beats memory every time. with a half-life of about 17.5 hours, a dose log also lets a tracker model the relative amount still in your system between doses.
Source
OpenFDA
Last reviewed 2026-06-11